The Research and Development Department of Caduceus USA, headed by Dr. Victor Niguel, researches new treatments aginst GUILT, and other diseases regarded as "incurable." In Under the Knife and Second Opinion, Niguel has Derek Stiles help with a puzzle to develop a new treatment for the Pempti Strain of GUILT. In New Blood, Caduceus USA is critisized on national TV by Dr. Leonardo Bello, but after Bello's defeat at the hands of Stigma Ops, Dr. Blaylock explained Caduceus's cause.

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