- "These GUILT are my children... Let's see you try to rebel against their might!"
During the raid on the Palmwood Plant, Derek and Angie come across Reina, wirelessly connected to a series of tanks. She explains that Aletheia is the secret to her appearance and glorifies the Neo-GUILT, calling it 'perfect', and offers to furnish all of her GUILT data in return for her freedom. Derek declines, and she taunts him, telling him that if she is removed from the plant against her will or killed, the plant will release a mist of GUILT, fatal to all who have incompatible DNA. Patrick injects a serum to activate Aletheia, hoping that the results could provide a way to revive his wife. The serum causes Reina's Aletheia to react violently and attack her body, causing Reina's body to age dramatically. Derek proceeds to treat her immediately and he succeeds. Afterwards, Reina seemingly returns to her youthful apperance, but it is unknown how.
- Reina has a Japanese last name, so one could assume that she is of Japanese heritage.
- Reina is the only person in the entire series to be operated twice in the same game, and that both of the operations invloved GUILT.