|Japanese Name||Itou Yuno (伊東優乃)|
|Age||29 (26 in Under the Knife)|
|Friends||Derek, Angie, Tyler Chase, Amy Chase|
Leslie Sears (joined Caduceus in 2012), is one of Caduceus' nurses featured in Trauma Center: Under the Knife, Under the Knife 2, and Second Opinion. She is almost always upbeat and jovial. Her positive attitude filters throughout the hospital, making her a popular nurse among patients.
- Leslie shares her first name with another nurse in New Blood (Leslie Newman).