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Anaesthesia is the process used to put the patient in a close to unconscious state, but does not halt the body's functions. The nervous system is temporarily disabled in this mode and allows surgeons to perform surgery on a patient without the patient feeling it or exhibiting pain from it.

The player doesn't have to initiate this themselves during gameplay, and is usually handled by an assisting doctor, and is particularly handled in Under the Knife, Under the Knife 2 and Second Opinion by Cybil Myers, who pertains expertise in this area.

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